Sociocultural Working Group Discussion

Notes on the Sociocultural Working Group discussion that took place May 3, 2011

Full Information Product Pricing: An Information Strategy for Harnessing Consumer Choice to Create a More Sustainable World

Research and practice in the information systems (IS) field have been evolving over time, nourishing and promoting the development of applications that transform the relationships of individuals, corporations, and governments. Building on this evolution, we push forward a vision of the potential influence of the IS field into one of the most important problems of our times, an increasingly unsustainable world, which is traditionally considered the product of imperfect markets or market externalities. We describe our work in Full Information Product Pricing (FIPP) and our vision of a FIPP global socio-technical system, I-Choose, as a way to connect consumer choice and values with environmental, social, and economic effects of production and distribution practices. FIPP and I-Choose represent a vision about how information systems research can contribute to interdisciplinary research in supply chains, governance, and market economies to provide consumers with information packages that help them better understand how, where, and by whom the products they buy are produced. We believe that such a system will have important implications for international trade and agreements, for public policy, and for making a more sustainable world

Smart cities and service integration

E-government advancements have not fully resolved the challenge of providing citizens with a single entry point for services that involve different government entities. The Smart Cities and Service Integration project (hereafter, SmartCities) aims to establish a framework for smart city service integration that would assist in the management of large scale projects related to the integration of services across governments. By using comparative case studies of six cities (New York City, Seattle, Quebec City, Mexico City, Macao, and Shanghai), the project aims to develop a theoretical framework to guide smart cities service integration. The project will highlight integration of public services and cross-boundary information sharing by focusing on specific policy domains. An additional goal of this project is to develop research capabilities of graduate students who participate in the research. The research project is funded by the Social Sciences and Humanities Research Council of Canada

Characterizing the heterogeneity of triple-negative breast cancers using microdissected normal ductal epithelium and RNA-sequencing

Triple-negative breast cancers (TNBCs) are a heterogeneous set of tumors defined by an absence of actionable therapeutic targets (ER, PR, and HER-2). Microdissected normal ductal epithelium from healthy volunteers represents a novel comparator to reveal insights into TNBC heterogeneity and to inform drug development. Using RNA-sequencing data from our institution and The Cancer Genome Atlas (TCGA) we compared the transcriptomes of 94 TNBCs, 20 microdissected normal breast tissues from healthy volunteers from the Susan G. Komen for the Cure Tissue Bank, and 10 histologically normal tissues adjacent to tumor. Pathway analysis comparing TNBCs to optimized normal controls of microdissected normal epithelium versus classic controls composed of adjacent normal tissue revealed distinct molecular signatures. Differential gene expression of TNBC compared with normal comparators demonstrated important findings for TNBC-specific clinical trials testing targeted agents; lack of over-expression for negative studies and over-expression in studies with drug activity. Next, by comparing each individual TNBC to the set of microdissected normals, we demonstrate that TNBC heterogeneity is attributable to transcriptional chaos, is associated with non-silent DNA mutational load, and explains transcriptional heterogeneity in addition to known molecular subtypes. Finally, chaos analysis identified 146 core genes dysregulated in >90 % of TNBCs revealing an over-expressed central network. In conclusion, use of microdissected normal ductal epithelium from healthy volunteers enables an optimized approach for studying TNBC and uncovers biological heterogeneity mediated by transcriptional chaos

Next-generation transcriptome sequencing of the premenopausal breast epithelium using specimens from a normal human breast tissue bank

Introduction Our efforts to prevent and treat breast cancer are significantly impeded by a lack of knowledge of the biology and developmental genetics of the normal mammary gland. In order to provide the specimens that will facilitate such an understanding, The Susan G. Komen for the Cure Tissue Bank at the IU Simon Cancer Center (KTB) was established. The KTB is, to our knowledge, the only biorepository in the world prospectively established to collect normal, healthy breast tissue from volunteer donors. As a first initiative toward a molecular understanding of the biology and developmental genetics of the normal mammary gland, the effect of the menstrual cycle and hormonal contraceptives on DNA expression in the normal breast epithelium was examined. Methods Using normal breast tissue from 20 premenopausal donors to KTB, the changes in the mRNA of the normal breast epithelium as a function of phase of the menstrual cycle and hormonal contraception were assayed using next-generation whole transcriptome sequencing (RNA-Seq). Results In total, 255 genes representing 1.4% of all genes were deemed to have statistically significant differential expression between the two phases of the menstrual cycle. The overwhelming majority (221; 87%) of the genes have higher expression during the luteal phase. These data provide important insights into the processes occurring during each phase of the menstrual cycle. There was only a single gene significantly differentially expressed when comparing the epithelium of women using hormonal contraception to those in the luteal phase. Conclusions We have taken advantage of a unique research resource, the KTB, to complete the first-ever next-generation transcriptome sequencing of the epithelial compartment of 20 normal human breast specimens. This work has produced a comprehensive catalog of the differences in the expression of protein-coding genes as a function of the phase of the menstrual cycle. These data constitute the beginning of a reference data set of the normal mammary gland, which can be consulted for comparison with data developed from malignant specimens, or to mine the effects of the hormonal flux that occurs during the menstrual cycle

Using Ontologies to Develop and Test a Certification and Inspection Data Infrastructure Building Block

Global markets for information-intensive products contain sharp information asymmetries that lead to market inefficiencies resulting from consumer purchasing decisions that are based on incomplete information. Elimination or reduction of such information asymmetries has long been the goal of governments as well as various nongovernmental entities that recognize that addressing issues such as sustainable production, socially just labor practices, and reduction in energy needs and health expenditure is closely linked to consumers being fully aware of the economic, environmental, and social impacts of their purchasing decisions. This chapter reports on the creation of ontology-enabled interoperable data infrastructure based on semantic technologies that would enable information sharing in traditionally information-restricted markets. The main technical result is a proof-of-concept set of data standards built on semantic technology applications and the functionalities of formal ontology of certification and inspection processes. The current proof of concept focuses specifically on certified fair-trade coffee, and while its applicability is currently limited, it has the potential to become universally applicable to any certification and inspection process for any product and service. In addition to producing a number of artifacts relevant to the expandability of the work, such as domain ontologies, the research indicates that while big data systems are necessary, they are not sufficient to create high levels of consumer trust. By testing the criteria using both hand-generated and automated queries, we are able to demonstrate that CIDIBB (Certification and Inspection Data Infrastructure Building Block) is not only able to test the trustworthiness of certification schemes but also that our ontology generates consistent results

Smart city as urban innovation: Focusing on management, policy, and context

This paper sees a smart city not as a status of how smart a city is but as a city’s effort to make itself smart. The connotation of a smart city represents city innovation in management and policy as well as technology. Since the unique context of each city shapes the technological, organizational and policy aspects of that city, a smart city can be considered a contextualized interplay among technological innovation, managerial and organizational innovation, and policy innovation. However, only little research discusses innovation in management and policy while the literature of technology innovation is abundant. This paper aims to fill the research gap by building a comprehensive framework to view the smart city movement as innovation comprised of technology, management and policy. We also discuss inevitable risks from innovation, strategies to innovate while avoiding risks, and contexts underlying innovation and risks